Introduction
This is an advanced guide and assumes a deep understanding of the boss's rotations and mechanics for the Hard Mode version of the Sanctum of Rebirth, found in Sanctum HM Mechanics Overview.
Presets and Relics
Vermyx, Brood Mother
⬥ Release all s
with 
Pre-fight
+ 
Phase 1
→ 
→ 
→ 
→ 
→ 
(
)
Coilspawn
→ (tc) 
→ 
→ → 
→ 
→ → s
Phase 2
+ r + → s → r →
Coilspawn
→ 
+ 
→ 
→ 
→ 
→ → 
→ 
→ s
Phase 3
r + 
→ 
→ 
→ → 
Kezalam, the Wanderer
⬥ Release all s with
War's Retreat
s
Enter the boss arena quickly so that your consumes the 
buff
Phase 1
r + → 4t s → 4t → → → 3t 
→ 
→ 
→ → → + 
md of pillar
Moonstone Obelisk 1
+ equip 
→ → 
+ → 
Phase 2
→ → → + → → → → → + → → 
Moonstone Obelisk 2
+ → → (do on Kezalam if obelisk dies)
Phase 3
→ → → → → → →
Nakatra, Devourer Eternal
⬥ Release all s with
⬥ This rotation assumes 
+ master attack cape perk
War's Retreat
s
Phase 1
r + → → → → → → → → s → r +
Phase 2
+ → 
→ → → → → s → r + → + 
→ 
+ 
→ →
If not yet phased → → → continue from below with available cooldowns
Phase 3
Nefthys 1
→ → → → + tick 2
Make certain you do not surge earlier, as this will null hits
Nefthys 2
→ → 
Prephase
4t → / → → 
Phase 4
Shadowsands
+ + → (tc) → (tc) → tc + (leave once it lands)
Nakatra
(2t tc) + → → + → s → r + → → → → → →
Example Kills
⬥ Vermyx 
⬥ Kezalam
⬥ Nakatra
Source record
By PvME contributors under CC BY-NC-SA 4.0. Navigation and typography adapted. Original sanitized source HTML and its text hash are retained separately. Source channel and message references are repaired using the pinned guide repository and public directory/identity evidence; navigation wording is adapted for the web. Every change is recorded in the reference repair ledger. Unverified destinations and contributor names remain explicitly unavailable. Legitimate external community and attribution links are preserved and labeled. Original media is embedded from providers; media rights are separate from guide-text rights.
Captured 2026-11-10T14:26:19Z. Game-version accuracy is unverified.
MediaWiki draft ↓